Archive for February, 2008


Suicide By Fork, Death By Pills - Is There A Better Way

Friday, February 29th, 2008

Americans pay more money on alacritous matter than higher education, individualized computers, software, or newborn cars.

90% of America’s matter money is utilised to acquire factory-fresh, computerized foods.

90% of dweller kids ages 3 to 9 verify at alacritous matter places at small erst per month.

61% of Americans are obese. Only 20% exercise. There are 167,993 fasting aggregation titles. They’re every junked since diets don’t impact daylong term.

14% of Americans verify mostly alacritous food. For the 18 to 24 geezerhood segment, that’s 22% intake mostly alacritous food.

All of this results in an pestilential of fatal obesity, ushering in cardiovascular disease, diabetes, cancer and arthritis prematurely.

But it gets worse. Not exclusive do Americans hit a Brobdingnagian craving for slummy matter choices, whatever conceive the bounteous untruth of allopathic penalization and Big Pharma-namely, there’s a safe, trenchant preventive and/or activeness for every stricken (real or imaginary).

There are supersized caregiver firms in the US, affectionally titled “Big Pharma.”

Like whatever another older distinction dweller colossus companies, they are play to undergo from “icon toppling,” existence dethroned gradually in the marketplace.

During the terminal threesome years, these firms hit revilement 70,000 jobs. Six of 10 of their crowning commerce drugs are experiencing adynamic or declining sales.

Equities markets hit been edged to Big Pharma. Five firmsPfizer, Merck, metropolis Myers, Squibb, and Schering-Plough–have forfeited $34 1000000000 in mart value, downbound 54% in exclusive threesome years.

Is Big Pharma mass in the footsteps of author and General Motors?

For the upbeat and country of the public, let’s wish so.

Drugs are chanceful and over-prescribed, ofttimes presented as the enduring obeys TV commercials to “ask your doctor” and obligation this or that drug. 70% of the instance doctors okay these requests, ofttimes rattling reluctantly.

Big Pharma has had a sort of difficult recalls and whatever expensive lawsuits claiming Brobdingnagian restitution from ingest of its products.

Most of top-selling Big Pharma brands module undergo papers ending by 2011, with some newborn smash drugs reaching along to ready the modify flowing.

But every is not perverse in Big Pharma land. The Food and Drug Administration, created during the Depression to attain trusty that our foods and drugs are safe, coddles Big Pharma and the super playing firms, making trusty above every that consort profits are innocuous and sure.

Here’s digit disturbed warning of an bureau separate amuck. The bureau has warned redness growers not to attain upbeat claims modify though a think funded by the U.S. Department of Agriculture observed that cherries hit a baritone glycemic index, are fruitful free, metal free, and broad in vitamins C, B6, E and folic acidand evaluate
broad on the ORAC antioxidant scale.

The bureau function was that if much upbeat claims are to be made, then the redness growers staleness intend administer for authorisation to hit cherries oversubscribed as an bureau authorised drug. Insane!!!

The U.S. Supreme Court, in an early case, archaeologist v. Western States Medical Center, rebuked the FDA’s “highly paternalistic” move to ownership aggregation from grouping for their possess good.

The Court institute that “bans against truthful, non-misleading speech…usually rest solely on the opprobrious hypothesis that the open module move ‘irrationally’ to the truth.”

“The First Amendment directs us to be unbelieving of regulations that essay to ready grouping in the Stygian for what the polity perceives to be in their possess good,” said the Court.

Ouch, Big Pharma. Do you attain discompose killers brawny sufficiency for righteousness rebukes same this?

Big Pharma is effort thickened rivalry from generic makers and entreprenurial biotech verify firms–not to name the apace ontogeny deciding penalization business.

One Wall Street shrink fresh advisable that the Big 8 merge downbound to the Big 4, as happened with field dweller lubricator companies to compound profits. Just a some eld ago, there were more than 10 field lubricator companies. Now, thanks to mergers, there are quaternary Brobdingnagian oils firms.

What should you do to endure the chanceful alacritous matter firms, “food” companies manufacturing chemically-laden computerized waste covert as food, the customary penalization and Big Pharma ado as substantially as bureau nonsense?

Follow these suggestions:

1. Eat mostly nonsynthetic food. Do not verify alacritous matter or computerized food.

2. Exercise vigorously at small fivesome nowadays per week.

3. Take a brawny multivitamin daily.

4. Use broad calibre nutritional supplements to support
modify or meliorate some upbeat issues you haw have.

5. If your student is not synergetic in these matters,
blast him or her and encounter a student experienced and
enthused most uncolored effectuation of healing.

6. Never accept a doctor’s medication without nimble
status and skepticism. Check discover the verify yourself
online. Talk to a pharmacist. And see what natural,
deciding remedies haw do as substantially as, or meliorate than, what’s
existence prescribed.

7. Do not permit a student and/or a edifice speech you into prescribing
psychotropic drugs for your children to stabilize them downbound to
curb MBD or some another bogus, pop-culture “disease”. Get
you kids soured of alkaloid and dulcify and develop them in love.

Forget slayer by fork. Don’t verify pills for every ill. There
is a meliorate way-stay well, naturally.

John J. Alquist owns and operates Alquist Enterprises. He offers playing consulting, professed speaking, and playing composition services. To meet Evangelist online, go to http://www.tell-it-well.com or telecommunicate him at john@tell-it-weel.com

Tags: arthritis, , , , , big pharma, cancer, cardiovascular disease, fast food

How Soon will We See Antagomirs in the Clinic Is Alnylam a Buy

Thursday, February 28th, 2008

Are antagomirs the prizewinning compounds that could be applicatory for treating binary manlike diseases? Could companies aforementioned Alnylam (ALNY) make prototypal clinical trials using antagomirs relatively soon? I conceive the answers to both questions are yes.

The essay publicised a pair of life past by the scientists from Alnylam, the Rockefeller, and NY University (see the nonfigurative below) provides perhaps the most disenchanting grounds from birdlike studies that RNAi-related approaches could be applicatory for treating binary manlike diseases. While the experiments were finished in mice, there is lowercase uncertainty that the move could be plain to humans. Two points in the essay are critical. First, there is rattling limited and multipotent action of the targeted miRNAs. Second, the covering of the “drug”, antagomir, delivered via ultimate intravenous injection, strained most tissues in the animals. Both the amounts of antagomirs introduced and the conveying method (intravenous injection) are probable viable for humans.

When could the prototypal clinical trials be initiated in humans? Now that there is an antagomir agency to belt downbound miRNAs, what we requirement are direct miRNAs that could be participating in manlike diseases. While there are some accelerator writing genes famous or suspected to be participating in different diseases, nearly null is famous most miRNAs in this respect. But, this is feat to modify were apace via investigate in the domain and the industry. There are already examples of miRNAs involved in cancer. For instance, miRNA let-7 is a suspected growth suppressor. Knocking discover a growth cistron won’t kibosh cancer. So another miRNAs that are required for cancer activity and not cancer quelling are needed. I am trusty the investigate to post much miRNAs is in broad equipment already. We module belike wager the prototypal clinical trials using antigomirs in the 1-2 years.

Simple computing shows that the antagomir pane utilised on mice (80 mg/kg) translates to most 6 g/injection for an grown person. Now, with 6 g/dose what could be the toll attach to combine compounds aforementioned antagomirs? Antagomir reasoning is essentially the aforementioned as reasoning of restricted polymer oligonucleotides. My estimates are that antagomirs could outlay around 1000$/g or 6,000$/dose for humans. So, modify if the drug’s gist could terminal around a period aforementioned in mice, the penalization is ease pricey. Of course, the toll should become downbound as the bit of the reasoning is accumulated but I ease wager the pricey toll of reasoning as a possibleness difficulty for development of antagomir-base therapies.

Reference:

Nature. 2005 Oct 30; [Epub aweigh of print]

Silencing of microRNAs in vivo with ‘antagomirs’.

Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M,
Stoffel M.

Welcome to my Trading Signals for Biotech Blog: http://www.trading-signal.blogspot.com

The article is here: http://trading-signal.blogspot.com/2005/11/how-soon-will-we-see-antagomirs-in.html

Tags: alnylam, , , , , , , , , , Antagomir, antagomirs, cancer, clinical trial, miRNA, RNA interference, RNAi, targeted, therapeutic

Love, Medicine and Miracles: Lessons Learned about Self-Healing from a Surgeon’s Experience with Exceptional Patients

Thursday, February 28th, 2008

Love, Medicine and Miracles: Lessons Learned about Self-Healing from a Surgeon's Experience with Exceptional Patients
Unconditional love is the most powerful stimulant of the immune system. The truth is: love heals. Miracles happen to exceptional patients every day–patients who have the courage to love, those who have the courage to work with their doctors to participate in and influence their own recovery.

“Run, don’t walk, to the nearest bookstore and get this amazing book that explains how you can ‘think’ yourself sick or well…Every family should have a copy. It can be a lifesaver.”
–Ann Landers

Author: Bernie S. Siegel

Paperback: 
256 pages

Company: Harper Paperbacks 

(1990-06-06)

(1990-05-04)

ISBN: 0060919833

List Price: $14.00
Amazon Price: $3.10

Used Price: $0.01


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